Updating the application and your GPU drivers should be your first action, but if that doesn’t work check the software’s documentation to see where you can toggle hardware acceleration off. Unfortunately, this sometimes means that the pointer disappears because of compatibility problems. This might happen because that application is trying to use hardware acceleration to render things more quickly and smoothly. Common examples include video player applications and web browsers such as Chrome. Sometimes a mouse pointer disappears only when it moves over certain applications. If Your Pointer Only Disappears in Certain Apps

It can also be that your GPU driver needs to be updated, so that it plays nicely with a newer mouse driver. Alternatively, perhaps you should roll back a new mouse driver which may be causing problems. While Windows usually does a good job of keeping things up to date, you may want to manually check that your mouse drivers are up to date. If your mouse has this feature, make sure it’s set to the correct profile for the computer you want to use it on. So you can switch between different devices at the touch of a button. Some Bluetooth mice, such as the MX Master series, support multiple device profiles.

Lenovo mouse pad not working windows 10